Angiogenesis: Biology and Pathology (Cold Spring Harbor Perspectives in Medicine)

Описание

The Generation Of The Vascular System Is An Important Part Of Embryonic Development. Formation Of New Blood Vessels That Supply Growing Tumors With Nutrients Is Also An Essential Aspect Of Cancer Progression. Work Pioneered By Researchers Such As Judah Folkman, To Whom This Book Is Dedicated, Has Illuminated The Mechanisms By Which New Blood Vessels Are Produced And The Vascular System As A Whole Is Patterned. The Contributors To This Volume Review Our Understanding Of The Mechanisms Of Angiogenesis, It S Role In Cancer And Other Pathologies, As Well As Therapeutic Approaches That Target Angiogenesis To Combat These Diseases. Endothelial Cell Heterogeneity / William C. Aird -- Human Endothelial Progenitor Cells / Mervin C. Yoder -- Vegf-directed Blood Vessel Patterning : From Cells To Organisms / Victoria L. Bautch -- Vegf And Notch In Tip And Stalk Cell Selection / Raquel Blanco And Holger Gerhardt -- Tips, Stalks, Tubes : Notch-mediated Cell Fate Determination And Mechanisms Of Tubulogenesis During Angiogenesis / Jennifer J. Tung, Ian W. Tattersall, And Jan Kitajewski -- Vascular Lumen Formation / Eckhard Lammert And Jennifer Axnick -- Mirnas As Modulators Of Angiogenesis / Shira Landskroner-eiger, Isabelle Moneke, And William C. Sessa -- Myeloid Cells And Lymphangiogenesis / Adrian Zumsteg And Gerhard Christofori -- The New Era Of The Lymphatic System : No Longer Secondary To The Blood Vascular System / Inho Choi, Sunju Lee, And Young-kwon Hong -- Vascular Development In The Zebrafish / Aniket V. Gore, Kathryn Monzo, Young R. Cha, Weijun Pan, And Brant M. Weinstein -- Molecular Parallels Between Neural And Vascular Development / Anne Eichmann And Jean-léon Thomas -- Signal Transduction By Vascular Endothelial Growth Factor Receptors / Sina Koch And Lena Claesson-welsh -- Vascular Hyperpermeability, Angiogenesis, And Stroma Generation / Janice A. Nagy, Ann M. Dvorak, And Harold F. Dvorak -- Pigf : A Multitasking Cytokine With Disease-restricted Activity / Mieke Dewerchin And Peter Carmeliet -- The Complex Role Of Angiopoietin-2 In The Angiopoietin- Tie Signaling Pathway / Gavin Thurston And Christopher Daly -- Molecular Basis For The Regulation Of Angiogenesis By Thrombospondin-1 And -2 / Patrick R. Lawler And Jack Lawler -- Semaphorins In Angiogenesis And Tumor Progression / Gera Neufeld, Adi D. Sabag, Noa Rabinovicz, And Ofra Kessler -- Tumor Endothelial Cells / Andrew C. Dudley -- Infantile Hemangioma - Mechanism(s) Of Drug Action On A Vascular Tumor / Shoshana Greenberger And Joyce Bischoff -- Endothelial Cell-to-cell Junctions : Adhesion And Signaling In Physiology And Pathology / Maria Grazia Lampugnani -- [lowercase Alpha]v Integrins In Angiogenesis And Cancer / Sara M. Weis And David A. Cheresh -- Vascular Normalization As A Therapeutic Strategy For Malignant And Nonmalignant Disease / Shom Goel, Andus Hon-kit Wong, And Rakesh K. Jain -- Antiangiogenic Therapy For Ischemic Retinopathies / Motasem Al-latayfeh, Paolo S. Silva, Jennifer K. Sun, And Lloyd Paul Aiello -- Angiogenic Factors In Preeclampsia And Related Disorders / Ana Sofia Cerdeira And S. Ananth Karumanchi -- The Role Of The Tumor Microenvironment In Regulating Angiogenesis / Randolph S. Watnick -- Common Polymorphisms In Angiogenesis / Michael S. Rogers And Robert J. D'amato -- Arteriovenous Malformations And Other Vascular Malformation Syndromes / Kevin J. Whitehead, Matthew C.p. Smith, And Dean Y. Li -- Vascular Anomalies : From Genetics Toward Models For Therapeutic Trials / Melanie Uebelhoer, Laurence M. Boom, And Miikka Vikkula -- Anti-vegf Therapies In The Clinic / Kellen L. Meadows And Herbert I. Hurwitz -- The Vegf Pathway In Cancer And Disease : Responses, Resistance, And The Path Forward / Mark W. Kieran, Raghu Kalluri, And Yoon-jae Cho. Edited By Michael Klagsbrun, Patricia A. D'amore. A Subject Collection From Cold Spring Harbor Perspectives In Medicine. Includes Bibliographical References And Index.

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