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Charles James Apperley, Welsh sportsman and sporting writer from an English family, and often resident in both countries, better known as Nimrod, the pseudonym under which he published his works on the chase and on the turf, was born at Plasgronow, near Wrexham, in Denbighshire, Wales in 1777.

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Charles James Fox, styled The Honourable from 1762, was a prominent British Whig statesman whose parliamentary career spanned 38 years of the late 18th and early 19th centuries. He was the arch-rival of the Tory politician William Pitt the Younger; his father Henry Fox, 1st Baron Holland, a leading Whig of his day, had similarly been the great rival of Pitt's famous father, William Pitt, 1st Earl of Chatham.

Charles Jennens was an English landowner and patron of the arts. As a friend of Handel, he helped author the libretti of several of his oratorios, most notably Messiah.

Sir Charles Hepburn Johnston, was a senior British diplomat and translator of Russian poetry.

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Charles Joret was a French literary historian, philologist and botanical author. His name is associated with the so-called ligne Joret, a locative boundary used in the linguistics (isogloss) of the Langues d'oïl.

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Charles Judson Herrick was an American neurobiologist who made comparative studies across vertebrate neural systems. Along with his brother Clarence Luther, he was a founding editor of the Journal of Comparative Neurology. He published several popular books including the Neurological Foundations of Animal Behavior (1924), The Brain of Rats and Men (1926), and The Thinking Machine (1928).

Charles Juliet in Jujurieux in Ain, is a French poet, playwright and novelist. He won the 2013 Prix Goncourt de la Poésie.

Charles Julius Hempel was a German-born translator and homeopathic physician who worked in the United States.

Charles Augustus Keeler was an American author, poet, ornithologist and advocate for the arts, particularly architecture.

Charles Kegan Paul, usually known as Kegan Paul, was an English author, publisher and former Anglican cleric. He began his adult life as a priest of the Church of England and held various ministry positions for more than 20 years. His religious orientation moved from the orthodoxy of the Church of England to first Agnosticism, then Positivism and finally Roman Catholicism.